CSR Biotech MI-SPIN 512

Intelligent Spinning Disk Condocal Microscope

• High Speed Dual Disk • Deep Sectioning Super-Resolution • Molecular Functional Quantification • AI-Assisted Imaging

MI-SPIN offers a highly versatile super resolution capable spinning disk confocal platform. The system is able to address wide variety of application including live cell imaging, high speed area scanning, deep tissue imaging and molecular functional imaging. Advance image processing capabilities and AI enabled workflow tools allow the system to deliver next generation performance.

• 8000 rpm dual disk rotation speed
• 100 nm resolution inn Spin-SACD
• 150 nm XY-resolution with sparse deconvolution 
• 30 mm ultra-large spin illumination FOV
• Excellent performance in high-throughput applications
• integrate FRAP and quantitative FRET molecular measurements

Exceeding the performance limits of the spinning disk confocal

Advanced optical design of high-speed dual disk system 

MI-SPIN integrates two high-speed dual disk (microlens array+pinhole array) with differentiated pinhole size, 25 µm and 50 µm engineered for deep optical sectioning in thick samples.

These two pinhole configurations perfectly balance imaging depth and resolution:

• 25 µm: preserves high resolution while rejecting out-of-focus signal, optimised for thick samples with strong background and complex structures
• 50 µm: extends imaging depth without sacrificing signal-to-noise (SNR), optimised for thick samples with low background and weak signals

MI-SPIN combines algorithm-assisted sectioning and dual disk hardward-sectioning to push the boundaries of deep super-resolution imaging. In WGA-stained mouse kidney sections. background subtraction and AI-Driven denoising effectively remove out-of-focus fluorescence and enhance image SNR to reveal fine structures.

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